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Comment
. 2014 Jan 23;123(4):463-4.
doi: 10.1182/blood-2013-12-539965.

Core fucosylation and IgG function in NAIT

Richard H Aster  1
Affiliations
Comment

Core fucosylation and IgG function in NAIT

Richard H Aster. Blood. .

Abstract

In this issue of Blood, Kapur et al show that maternal human platelet-specific antigen 1a (HPA 1a)-specific antibodies causing neonatal alloimmune thrombocytopenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of antibody-coated platelets.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Representative IgG-associated glycans with (left) and without (right) a core fucosyl residue (red triangle). Other saccharides are N-acetylglucosamine (blue), mannose (green), galactose (orange), and sialic acid (purple). “p” designates glycan-bound peptide in tryptic digest subjected to mass spectroscopic analysis. Professional illustration by Alice Y. Chen.
See this image and copyright information in PMC

Comment on

  • A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy.
    Kapur R, Kustiawan I, Vestrheim A, Koeleman CA, Visser R, Einarsdottir HK, Porcelijn L, Jackson D, Kumpel B, Deelder AM, Blank D, Skogen B, Killie MK, Michaelsen TE, de Haas M, Rispens T, van der Schoot CE, Wuhrer M, Vidarsson G. Kapur R, et al. Blood. 2014 Jan 23;123(4):471-80. doi: 10.1182/blood-2013-09-527978. Epub 2013 Nov 15. Blood. 2014. PMID: 24243971 Free PMC article.

References

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    1. Shields RL, Lai J, Keck R, et al. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J Biol Chem. 2002;277(30):26733–26740. - PubMed

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