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Case Reports
. 2014 Feb;464(2):247-51.
doi: 10.1007/s00428-014-1542-5. Epub 2014 Jan 24.

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Elise M Bekers  1 , Adriana C H van Engen-van Grunsven, Patricia J T A Groenen, Harm Westdorp, Rutger H T Koornstra, Johannes J Bonenkamp, Uta Flucke, Willeke A M Blokx
Affiliations
Case Reports

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Elise M Bekers et al. Virchows Arch. 2014 Feb.

Abstract

Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

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