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Comment
. 2014 Feb 11;111(6):2056-7.
doi: 10.1073/pnas.1323189111. Epub 2014 Jan 23.

Refining a key metabolic innovation in Escherichia coli

Sergey Kryazhimskiy  1 , Michael M Desai
Affiliations
Comment

Refining a key metabolic innovation in Escherichia coli

Sergey Kryazhimskiy et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) One or more mutations (yellow) that potentiated the evolution of citrate utilization arose by generation 20,000 of the LTEE. This was followed by the rnk-citG actualizing mutation (orange) that conferred a weak Cit+ phenotype, which was later refined (blue) into the strong Cit++ phenotype. More than 70 other mutations (gray) also accumulated during this time. Backcrossing, selection, and sequencing allowed Quandt et al. to isolate mutations necessary for the Cit++ phenotype; this did not include the original potentiating mutation(s). (B) A possible fitness landscape for the evolution of Cit++ phenotype. Thick and thin arrows show confirmed and hypothesized fitness effects of potentiating (P), actualizing (A), and refinement (R) mutations; orange arrows show the actual path taken by the evolving population.
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