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. 2014 Nov;27(16):1719-21.
doi: 10.3109/14767058.2013.871630. Epub 2014 Feb 7.

Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series

Irena Kessel  1 , Dan Waisman, Karen Lavie-Nevo, Marcelo Golzman, Avraham Lorber, Avi Rotschild
Affiliations

Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series

Irena Kessel et al. J Matern Fetal Neonatal Med. 2014 Nov.

Abstract

Paracetamol was reported to be effective for patent ductus arteriosus (PDA) closure. We present a case series of PDA closure by paracetamol in seven premature infants. During the treatment, paracetamol blood levels did not exceed the recommended levels for analgesia and hyperthermia in six tested infants. None of the patients demonstrated significant disturbances of liver function.

Keywords: Blood level; closure; paracetamol; patent ductus arteriosus.

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