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. 2014 Oct;20(10):O772-5.
doi: 10.1111/1469-0691.12567. Epub 2014 Mar 6.

Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

F Valour  1 , J Tasse, S Trouillet-Assant, J-P Rasigade, B Lamy, E Chanard, P Verhoeven, J-W Decousser, H Marchandin, M Bès, C Chidiac, F Vandenesch, T Ferry, F Laurent; Lyon Bone and Joint Infection study group
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Free article

Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage

F Valour et al. Clin Microbiol Infect. 2014 Oct.
Free article

Abstract

The prevalence of clonal complex (CC) 398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates.

Keywords: Clonal complex 398; bone and joint infection; methicillin-susceptible Staphylococcus aureus; molecular epidemiology; nasal carriage; virulence factors.

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