The development of the corticotectal pathway in the albino rat: transient projections from the visual and motor cortices

Abstract

In rats ranging in age from the second postnatal day (23rd postconceptional day-23 PCD) to adulthood, we have studied the distribution of corticotectal terminals labelled anterogradely by unilateral injections of horseradish peroxidase (conjugated with wheat germ agglutinin) into the visual or motor cortices. No projection to the contralateral superior colliculus (SC) was observed. The earliest age at which the labelled axons and/or terminals from the visual cortex were observed in the ipsilateral SC was 25 PCD. At this stage the projection only involves the optic layer. From 28 to 34 PCD, the projection involves the optic layer, the intermediate layers and the deep part of superficial gray layer. Between 34 and 40 PCD the projection becomes restricted to the superficial laminae (i.e. adultlike). On the 23 PCD (the earliest age examined) we observed a projection from the motor cortex to the intermediate laminae and to a lesser extent the optic layer of the ipsilateral SC. By 34 PCD only the adult-like projection extending from the brachium to the periaqueductal gray (PAG) is apparent. The disappearance of the transient projections to the intermediate collicular laminae may be the result of withdrawal of 'misprojecting' axonal collaterals.