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Observational Study
. 2014 Jun;68(6):572-80.
doi: 10.1016/j.jinf.2013.12.018. Epub 2014 Jan 23.

Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries

Elizabeth Stankiewicz Machado  1 , Margot R Krauss  2 , Karen Megazzini  2 , Conrado Milani Coutinho  3 , Regis Kreitchmann  4 , Victor Hugo Melo  5 , José Henrique Pilotto  6 , Mariana Ceriotto  7 , Cristina B Hofer  8 , George K Siberry  9 , D Heather Watts  9 ; NICHD International Site Development Initiative (NISDI) Pediatric Protocol
Collaborators, Affiliations
Observational Study

Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries

Elizabeth Stankiewicz Machado et al. J Infect. 2014 Jun.

Abstract

Objectives: To evaluate the incidence of and risk factors for hypertensive disorders in a cohort of HIV-infected pregnant women.

Methods: Hypertensive disorders (HD) including preeclampsia/eclampsia (PE/E) and pregnancy induced hypertension, and risk factors were evaluated in a cohort of HIV-infected pregnant women from Latin America and the Caribbean enrolled between 2002 and 2009. Only pregnant women enrolled for the first time in the study and delivered at ≥20 weeks gestation were analyzed.

Results: HD were diagnosed in 73 (4.8%, 95% CI: 3.8%-6.0%) of 1513 patients; 35 (47.9%) had PE/E. HD was significantly increased among women with a gestational age-adjusted body mass index (gBMI) ≥25 kg/m(2) (OR = 3.1; 95% CI: 1.9-5.0), hemoglobin (Hg) ≥11 g/dL at delivery (OR = 2.1; 95% CI: 1.2-3.6) and age ≥35 years (OR = 1.8; 95% CI: 1.1-3.2). PE/E was increased among women with a gBMI ≥25 kg/m(2) (OR = 3.0; 95% CI: 1.5-6.0) and Hg ≥11 g/dL at delivery (OR = 2.8; 95% CI: 1.2-6.5). A previous history of PE/E increased the risk of PE/E 6.7 fold (95% CI: 1.8-25.5). HAART before conception was associated with PE/E (OR = 2.3; 95% CI: 1.1-4.9).

Conclusions: HIV-infected women, with a previous history of PE/E, a gBMI ≥25 kg/m(2), Hg at delivery ≥11 g/dL and in use of HAART before conception are at an increased risk of developing PE/E during pregnancy.

Keywords: Eclampsia; HIV-infected women; Hypertensive disorders; Preeclampsia; Pregnancy.

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Figures

Figure 1
Figure 1
Derivation of Study Population
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