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. 2014 Jan;123(1):126-133.
doi: 10.1097/AOG.0000000000000054.

Blood transfusion during pregnancy, birth, and the postnatal period

Jillian A Patterson  1 , Christine L Roberts, Jennifer R Bowen, David O Irving, James P Isbister, Jonathan M Morris, Jane B Ford
Affiliations

Blood transfusion during pregnancy, birth, and the postnatal period

Jillian A Patterson et al. Obstet Gynecol. 2014 Jan.

Abstract

Objectives: To identify risk factors for transfusion and trends in transfusion rates across pregnancy and the postnatal period.

Methods: Linked hospital and birth data on all births in hospitals in New South Wales, Australia, between 2001 and 2010 were used to identify blood transfusions for women during pregnancy, at birth, and in the 6 weeks postpartum. Poisson regression was used to identify risk factors for red cell transfusion in the birth admission. Separate models were fitted for cesarean and vaginal births.

Results: Between 2001 and 2010, there were 12,147 transfusions across 891,914 pregnancies, with a transfusion rate of 1.4%. The transfusion rate increased steadily from 1.2% in 2001 to 1.6% in 2010. The majority of transfusions (91%) occurred during the birth admission, and 81% of these transfusions were associated with a diagnosis of hemorrhage. Women with bleeding or platelet disorders (vaginal: number transfused 529, relative risk [RR] 7.8, 99% confidence interval [CI] 6.9-8.7, cesarean: n=592, RR 8.7, CI 7.7-9.7) and placenta previa: (vaginal n=73, RR 4.6, CI 3.4-6.3, cesarean: n=875, RR 5.7, CI 5.1-6.4) were at highest risk of transfusion. Among vaginal births, increased risk was evident for forceps (n=1,036, RR 2.8, CI 2.5-3.0) or vacuum births (n=1,073, RR 1.9, CI 1.7-2.0) compared with nonoperative births.

Conclusions: Rates of obstetric blood product transfusion have increased by 33% since 2001, with the majority of this associated with hemorrhage. Women with bleeding or platelet disorders and placenta previa are at increased risk of transfusion and should be treated accordingly.

Level of evidence: II.

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References

    1. Thomson A, Farmer S, Hofmann A, Isbister J, Shander A. Patient blood management—a new paradigm for transfusion medicine? ISBT Sci Ser 2009;4:423–35.
    1. Goodnough LT, Shander A. Patient blood management. Anesthesiology 2012;116:1367–76.
    1. Shander A, Van Aken H, Colomina MJ, Gombotz H, Hofmann A, Krauspe R, et al.. Patient blood management in Europe. Br J Anaesth 2012;109:55–68.
    1. Roberts CL, Ford JB, Algert CS, Bell JC, Simpson JM, Morris JM. Trends in adverse maternal outcomes during childbirth: a population-based study of severe maternal morbidity. BMC Pregnancy Childbirth 2009;9:7.
    1. Knight M, Callaghan WM, Berg C, Alexander S, Bouvier-Colle MH, Ford JB, et al.. Trends in postpartum hemorrhage in high resource countries: a review and recommendations from the International Postpartum Hemorrhage Collaborative Group. BMC Pregnancy Childbirth 2009;9:55.

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