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Editorial
. 2014 Aug;60(2):464-7.
doi: 10.1002/hep.27032. Epub 2014 May 27.

How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations

Jonathan A Dranoff  1 , Jordan J Feld, Elise G Lavoie, Michel Fausther
Affiliations
Editorial

How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations

Jonathan A Dranoff et al. Hepatology. 2014 Aug.
No abstract available

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Figures

Figure 1
Figure 1. Proposed mechanism for the anti-fibrotic effect of caffeine in chronic liver disease
Caffeine is a known antagonist of the A2a adenosinergic receptor expressed on activated hepatic stellate cells and other liver myofibroblasts. Stimulation of the A2aAR has several downstream pro-fibrogenic effects, including rearrangement of stress fibers, chemotaxis in response to PDGF and other stimuli, and secretion of fibrillar collagen, all of which may be inhibited by caffeine.
See this image and copyright information in PMC

References

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