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Randomized Controlled Trial
. 2014 Jan 2;11(2):116-26.
doi: 10.7150/ijms.7073. eCollection 2014.

Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of safety

A William Kedia  1 , Jennifer E Hofheins  1 , Scott M Habowski  1 , Arny A Ferrando  2 , M David Gothard  3 , Hector L Lopez  1
Affiliations
Randomized Controlled Trial

Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of safety

A William Kedia et al. Int J Med Sci. .

Abstract

In this prospective, randomized, double-blind, trial conducted in two parts, we examined the effects of a multi-ingredient pre-exercise workout supplement blend of creatine, betaine and a dendrobium extract (MMP) on safety, performance, and body composition in healthy men and women undergoing a supervised program of resistance exercise. Part 1 was an acute hemodynamic safety study wherein forty young, healthy men and women (26.2 ± 5.3 years, 70.4 ± 3.3 inches, 83.7 ± 14.9 kg, 26.0 ± 3.2 kg●m(-2)) ingest one dose of either the MMP or comparator in a randomized, double-blind, comparator controlled, crossover fashion before having their resting heart rate, blood, ECG and comprehensive blood chemistry and blood counts completed. Systolic (SBP) and diastolic (DBP) blood pressures were generally raised (3.0-5.4 mm Hg, p<0.01) following supplementation with MPP whereas in the comparator group SBP was marginally reduced by 0.3 to 1.2 mm Hg, p>0.05 at all time points) and DBP was increased (3.0 - 3.9 mm Hg, p<0.05 at all time points). No changes in EKG-corrected QT interval were observed, and no serious adverse events were reported. Part 2 was a six-week training study wherein forty-three young, healthy men and women (24.3 ± 2.9 years, 70.5 ± 3.1 inches, 83.8 ± 9.6 kg, 26.1 ± 2.7 kg●m(-2)) supplemented with daily pre-workout doses of either the MPP or a comparator in a randomized, double-blind, comparator-controlled fashion while following a standardized resistance training program for six weeks. MPP and the comparator were isocaloric and delivered the same amount of caffeine. Significant improvements in visual analog scale (VAS) scores for energy (p<0.024) and concentration (p<0.041) were found along with consistently higher levels of focus accompanied by less fatigue when MPP was consumed in comparison to comparator during upper body muscular strength-endurance tests at weeks 3 and 6. MPP supplementation for 6 weeks did not improve dual-energy x-ray absorptiometry (DEXA) measures of body composition or objective assessments of exercise performance. Overall, MPP use and administration was well tolerated. Self-reported scores for energy and concentration were significantly greater. Over a six-week training and supplementation period, MPP use was not associated with improvements in performance or body composition. Future studies should confirm these effects over a more prolonged training period.

Keywords: botanicals; caffeine; creatine; dendrobium; dietary supplement; pre-workout; safety; sports nutrition.

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Conflict of interest statement

Competing Interests: The authors declare that they have no competing or financial interests concerning the outcome of this investigation. The sponsor of this study, Driven Sports, Inc. (Franklin Square, NY) provided an independent research grant and donated product, but had no role in the collection, analyses, or interpretation of the data.

Figures

Figure 1
Figure 1
MPP supplement facts panel.
Figure 2
Figure 2
Efficacy endpoints: time-course of energy.
Figure 3
Figure 3
Efficacy endpoints: time-course of concentration.
See this image and copyright information in PMC

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