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Comment
. 2014 Jan;10(1):e1004104.
doi: 10.1371/journal.pgen.1004104. Epub 2014 Jan 23.

The sense and sensibility of strand exchange in recombination homeostasis

Francesca Cole  1
Affiliations
Comment

The sense and sensibility of strand exchange in recombination homeostasis

Francesca Cole. PLoS Genet. 2014 Jan.
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Homeostatic regulation of meiotic recombination.
Wild-type meiosis, which has a marked preference for interhomolog recombination, is shown at the top. Dashed lines indicate recombination-dependent interactions that can occur either between sisters or homologs. A proportion of interhomolog interactions will become crossovers that exchange flanking genetic information between homologs and are required for accurate chromosome segregation. The remaining interhomolog interactions are likely to become noncrossovers, which constitute a patch-like repair at the site of the break and do not exchange flanking markers. Aberrant meiosis with reduced homolog bias is shown at the bottom. Additional DNA double-strand breaks (DSBs) are proposed to form in response to reduced interhomolog interactions. Further, when the frequency of successful interhomolog interactions is reduced, the ratio of crossover to noncrossover outcomes is increased. Together, the two types of homeostatic regulation work to maintain crossover number and distribution.
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