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. 1987 Oct;46(10):746-9.
doi: 10.1136/ard.46.10.746.

Antibodies to intermediate filaments in polymyalgia rheumatica and giant cell arteritis: a sequential study

B Dasgupta  1 , O Duke, V Kyle, D G Macfarlane, B L Hazleman, G S Panayi
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Antibodies to intermediate filaments in polymyalgia rheumatica and giant cell arteritis: a sequential study

B Dasgupta et al. Ann Rheum Dis. 1987 Oct.

Abstract

Serum specimens from 35 patients with polymyalgia rheumatica and giant cell arteritis (PMR/GCA) were obtained sequentially at variable time intervals up to a year from onset of disease. These were tested for antibodies to intermediate filaments by indirect immunofluorescence using HEp2 cells as substrate. Twenty four of 35 (68%) patients' sera at onset of disease were positive at an anti-intermediate filament antibody (AIFA) titre of greater than 1/40 compared with three outs of 19 (15%) control sera. AIFA were predominantly of IgM class, and there was no significant change in AIFA titres on follow up despite clinical remission of disease.

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References

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