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. 2014 Apr;104(1):e26-8.
doi: 10.1016/j.diabres.2013.12.061. Epub 2014 Jan 8.

The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward?

G Barbarossa  1 , A Renzi  1 , L D'Erasmo  1 , A Gallo  1 , E Grieco  1 , M Rossetti  1 , A Carnovale  1 , M Santilli  1 , E Mandosi  1 , P Coletta  1 , D Pergolini  1 , S Morano  1 , M Maranghi  2
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The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward?

G Barbarossa et al. Diabetes Res Clin Pract. 2014 Apr.

Abstract

Low high-density lipoprotein cholesterol (HDL-C) levels are associated with cardiovascular (CV) disease in type 2 diabetes (T2D). Unfortunately available drugs to increase HDL-C have failed to demonstrate a reduction in CV risk. We assessed the effect of improving glycemic control on HDL-C levels. A 6-month intervention resulted in significant improvement in HbA1c but not in HDL-C levels. However, when considering the subgroup of subjects with low levels of HDL-C at baseline, we found a significant and inverse relation between improvement in HbA1c and HDL-C levels.

Keywords: Glycated haemoglobin; Glycemic control; HDL-cholesterol; Type 2 diabetes.

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