Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Mar;146(3):602-4.
doi: 10.1053/j.gastro.2014.01.041. Epub 2014 Jan 24.

Differentiating Lynch-like from Lynch syndrome

Affiliations
Editorial

Differentiating Lynch-like from Lynch syndrome

John M Carethers. Gastroenterology. 2014 Mar.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Nakagawa H, Sotamaa K, Prior TW, Westman J, Panescu J, Fix D, Lockman J, Comeras I, de la Chapelle A. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851–60. - PubMed
    1. Carethers JM. DNA Testing and Molecular Screening for Colon Cancer. Clin Gastroenterol Hepatol. 2013 Dec 16; pii: S1542-3565(13)01933-2. doi: 10.1016/j.cgh.2013.12.007. [Epub ahead of print] - PMC - PubMed
    1. Ligtenberg MJ, Kuiper RP, Chan TL, Goossens M, Hebeda KM, Voorendt M, Lee TY, Bodmer D, Hoenselaar E, Hendriks-Cornelissen SJ, Tsui WY, Kong CK, Brunner HG, van Kessel AG, Yuen ST, van Krieken JH, Leung SY, Hoogerbrugge N. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1. Nat Genet. 2009;41:112–7. - PubMed
    1. Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology. 2008;135:1079–99. - PMC - PubMed
    1. Miyakura Y, Sugano K, Konishi F, Ichikawa A, Maekawa M, Shitoh K, Igarashi S, Kotake K, Koyama Y, Nagai H. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology. 2001;121:1300–9. - PubMed

MeSH terms

Supplementary concepts