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Review
. 2014 Mar;22(3):138-46.
doi: 10.1016/j.tim.2013.12.011. Epub 2014 Jan 24.

Global spread of dengue virus types: mapping the 70 year history

Jane P Messina  1 , Oliver J Brady  2 , Thomas W Scott  3 , Chenting Zou  2 , David M Pigott  2 , Kirsten A Duda  2 , Samir Bhatt  2 , Leah Katzelnick  4 , Rosalind E Howes  2 , Katherine E Battle  2 , Cameron P Simmons  5 , Simon I Hay  6
Affiliations
Review

Global spread of dengue virus types: mapping the 70 year history

Jane P Messina et al. Trends Microbiol. 2014 Mar.

Abstract

Since the first isolation of dengue virus (DENV) in 1943, four types have been identified. Global phenomena such as urbanization and international travel are key factors in facilitating the spread of dengue. Documenting the type-specific record of DENV spread has important implications for understanding patterns in dengue hyperendemicity and disease severity as well as vaccine design and deployment strategies. Existing studies have examined the spread of DENV types at regional or local scales, or described phylogeographic relationships within a single type. Here we summarize the global distribution of confirmed instances of each DENV type from 1943 to 2013 in a series of global maps. These show the worldwide expansion of the types, the expansion of disease hyperendemicity, and the establishment of an increasingly important infectious disease of global public health significance.

Keywords: dengue; serotypes.

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Figures

Figure 1
Figure 1
Spatial distribution of reported confirmed cases of DENV1 since 1943. Darker-colored areas represent cases that were confirmed in the given decade under consideration, whereas lighter-colored areas represent cases that had been previously reported but not in the current decade.
Figure 2
Figure 2
Spatial distribution of reported confirmed cases of DENV2 since 1943. Darker-colored areas represent cases that were confirmed in the given decade under consideration, whereas lighter-colored areas represent cases that had been previously reported but not in the current decade.
Figure 3
Figure 3
Spatial distribution of reported confirmed cases of DENV3 since 1943. Darker-colored areas represent cases that were confirmed in the given decade under consideration, whereas lighter-colored areas represent cases that had been previously reported but not in the current decade.
Figure 4
Figure 4
Spatial distribution of reported confirmed cases of DENV4 since 1943. Darker-colored areas represent cases that were confirmed in the given decade under consideration, whereas lighter-colored areas represent cases that had been previously reported but not in the current decade.
Figure 5
Figure 5
DENV Co-circulation. Cumulative number of DENV types reported by decade since 1943.
See this image and copyright information in PMC

References

    1. Gubler D.J. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002;10:100–103. - PubMed
    1. Holmes E.C., Twiddy S.S. The origin, emergence and evolutionary genetics of dengue virus. Infection, genetics and evolution. 2003;3:19–28. - PubMed
    1. Wang E. Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J. Virol. 2000;74:3227–3234. - PMC - PubMed
    1. Hotta S. Experimental studies on dengue. I. Isolation, identification and modification of the virus. J. Infect. Dis. 1952;90:1–9. - PubMed
    1. Mousson L. Phylogeography of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) based on mitochondrial DNA variations. Genet. Res. 2005;86:1–11. - PubMed