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. 1987 Oct 6;142(1):169-72.
doi: 10.1016/0014-2999(87)90670-4.

Tetrahydroaminoacridine blocks voltage-dependent ion channels in hippocampal neurons

M A Rogawski  1
Affiliations

Tetrahydroaminoacridine blocks voltage-dependent ion channels in hippocampal neurons

M A Rogawski. Eur J Pharmacol. .

Abstract

Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that may produce functional improvement in patients with Alzheimer's disease. Because of its structural similarity to the potassium channel (A-current) blocking drug 4-aminopyridine (4-AP), it has been speculated that some of the therapeutic benefit of THA might result from inhibition of potassium currents. In the present study, THA produced a dose-dependent, reversible block of the A-current in cultured hippocampal neurons (IC50, 30 microM). However, at similar concentrations it also inhibited other voltage-dependent currents.

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