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. 2014 May;23(4):626-32.
doi: 10.1007/s10646-014-1194-x. Epub 2014 Jan 29.

Toxicity of phthalate esters exposure to carp (Cyprinus carpio) and antioxidant response by biomarker

Xiaoxiang Zhao  1 , Ying Gao, Mingliang Qi
Affiliations

Toxicity of phthalate esters exposure to carp (Cyprinus carpio) and antioxidant response by biomarker

Xiaoxiang Zhao et al. Ecotoxicology. 2014 May.

Abstract

To study the toxic effects of phthalate esters on the aquatic creatures, carps were exposed to dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) of six different concentrations for 96 h-LC50 measurements. It shows that the 96 h-LC50 is 16.30 and 37.95 mg L(-1), thus the safe concentration (1/10LC(50)) is 1.63 mg L(-1). The activities of xanthine oxidase (XOD) and catalase (CAT) were measured in liver to carp exposure for single or combinations of DBP and DEHP. The quantity of malonic dialdehyde (MDA) was also measured in the same way. XOD, CAT and MDA had shown an evident change while exposure time and concentration increased, combined exposure can aggravate this change. They might be used as early warning indicators and monitors, and have potentials in the ecological risk assessment.

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Figures

Fig. 1
Fig. 1
DBP (a) and DEHP (b) influence on XOD activity
Fig. 2
Fig. 2
DBP (a) and DEHP (b) influence on CAT activity
Fig. 3
Fig. 3
DBP (a) and DEHP (b) influence on MDA
Fig. 4
Fig. 4
Single and combination of DBP and DEHP influence on a XOD activity, b CAT activity and c MDA activity
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