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. 2014 Mar;90(3):418-21.
doi: 10.4269/ajtmh.12-0660. Epub 2014 Jan 27.

Dengue virus serotype 1 non-structural protein NS5 expression interferes with HIV replication in a CD4+ T-cell line

Uriel A López-Lemus  1 , Clemente Vásquez, Roberto Vázquez-Campuzano, Salvador Valle-Reyes, Carmen Guzmán-Bracho, Diego Araiza-Garaygordobil, Nicte Rebolledo-Prudencio, Iván Delgado-Enciso, Francisco Espinoza-Gómez
Affiliations

Dengue virus serotype 1 non-structural protein NS5 expression interferes with HIV replication in a CD4+ T-cell line

Uriel A López-Lemus et al. Am J Trop Med Hyg. 2014 Mar.
No abstract available

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Figures

Figure 1.
Figure 1.
Design of the expression construct. (Upper panel) Organization of DENV genome including untranslated regions (NTRs). (Lower panel) NS5 gene was inserted into a pIRES2-EGFP vector. A stop codon was added at the end of the NS5 gene.
Figure 2.
Figure 2.
The DENV1 NS5 protein interferes with HIV replication in Jurkat CD4+ T cells. (A) The percentage of HIV p24 antigen reactivity in CD4+ T cells that are transfected with NS5 and not transfected. *P < 0.01. (B) The percentage of p24 antigen reactivity over a period of 7 study days; 25 pg/mL HIV p24 antigen were taken as 100% reactivity. *P < 0.02; **P < 0.005.
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