Reply to D’Amato et al. and Zeldis et al.: Screening of thalidomide derivatives in chicken and zebrafish embryos
- PMID: 24471177
- PMCID: PMC3864311
- DOI: 10.1073/pnas.1318475110
Reply to D’Amato et al. and Zeldis et al.: Screening of thalidomide derivatives in chicken and zebrafish embryos
Conflict of interest statement
The authors declare no conflict of interest.
Comment on
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Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro.Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12703-8. doi: 10.1073/pnas.1307684110. Epub 2013 Jul 15. Proc Natl Acad Sci U S A. 2013. PMID: 23858438 Free PMC article.
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Pomalidomide is teratogenic in rats and rabbits and can be neurotoxic in humans.Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4819. doi: 10.1073/pnas.1317084110. Epub 2013 Dec 3. Proc Natl Acad Sci U S A. 2013. PMID: 24302769 Free PMC article. No abstract available.
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Pomalidomide is strongly antiangiogenic and teratogenic in relevant animal models.Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4818. doi: 10.1073/pnas.1315875110. Epub 2013 Dec 3. Proc Natl Acad Sci U S A. 2013. PMID: 24302770 Free PMC article. No abstract available.
References
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- Ferguson GD, et al. Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2. J Clin Immunol. 2007;27(2):210–220. - PubMed
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- Lentzsch S, et al. S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice. Cancer Res. 2002;62(8):2300–2305. - PubMed
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