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Case Reports
. 2014 Jun;21(2):124-7.
doi: 10.3109/13506129.2013.854205. Epub 2014 Jan 29.

Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

Gottfried von Keudell  1 , Vaishali Sanchorawala, Carl O'Hara, David C Seldin, J Mark Sloan
Affiliations
Case Reports

Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

Gottfried von Keudell et al. Amyloid. 2014 Jun.

Abstract

We report on a 58-year-old man who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted plasma cell dyscrasia causing AL amyloidosis involving the kidney and GI tract. While monoclonal immunoglobulins occasionally produced by CLL has previously been implicated in AL amyloidosis, this is the first case of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL. Appropriate treatment depended on detailed pathologic diagnosis of both disease processes.

Keywords: AL amyloidosis; CLL; plasma cell dyscrasia.

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