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Comparative Study
. 2014 Jan 28;43(1):4.
doi: 10.1186/1916-0216-43-4.

Management of locally advanced laryngeal cancer

Alexander D Karatzanis, Georgios Psychogios, Frank Waldfahrer, Markus Kapsreiter, Johannes Zenk, George A Velegrakis, Heinrich Iro  1
Affiliations
Comparative Study

Management of locally advanced laryngeal cancer

Alexander D Karatzanis et al. J Otolaryngol Head Neck Surg. .

Abstract

Background: Management of advanced laryngeal cancer is complex and ideal strategy is yet to be defined. This study evaluates the experience of a single head and neck oncologic centre in the management of T4 laryngeal cancer.

Methods: Retrospective assessment of cases primarily treated for T4a squamous cell carcinoma of the larynx, between 1980 and 2007, at a tertiary referral center.

Results: A total of 384 cases were studied. Five-year disease specific survival was 56.2% and local control 87.4%. Regional and distal control estimates were 90.3% and 88.3% respectively. Prognosis was significantly superior for cases treated with primary surgery compared to cases solely managed with non-surgical modalities. Positive surgical margins and regional disease worsened prognosis.

Conclusion: This study suggests that primary surgery remains a key element in the treatment of advanced laryngeal cancer. The need for well-designed, prospective, randomised studies in order to further evaluate the remaining role of primary surgery in the modern management of locally advanced laryngeal lesions is emphasized.

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Figures

Figure 1
Figure 1
Kaplan-Meier analysis of disease specific survival (DSS) in accord with primary treatment.
Figure 2
Figure 2
Kaplan-Meier analysis of disease specific survival (DSS) in accord with status of surgical margins (R). R0: negative surgical margins. R+: positive surgical margins.
See this image and copyright information in PMC

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