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. 2014 May;133(5):1471-4.
doi: 10.1016/j.jaci.2013.11.039. Epub 2014 Jan 25.

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities

Jonathan J Lyons  1 , Guangping Sun  1 , Kelly D Stone  1 , Celeste Nelson  1 , Laura Wisch  1 , Michelle O'Brien  1 , Nina Jones  2 , Andrew Lindsley  3 , Hirsh D Komarow  1 , Yun Bai  1 , Linda M Scott  1 , Daly Cantave  4 , Irina Maric  5 , J Pablo Abonia  3 , Marc E Rothenberg  3 , Lawrence B Schwartz  6 , Joshua D Milner  7 , Todd M Wilson  8
Affiliations

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities

Jonathan J Lyons et al. J Allergy Clin Immunol. 2014 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest

The NIH authors declare no conflict of interest. LBS receives royalties from VCU that are collected from ThermoFisher for the tryptase UniCAP assay. MER has received consultancy fees from Immune Pharmaceuticals; has patents owned by CCHMC; may receive royalties from Teva Pharmaceuticals; and has stock/stock options in Immune Pharmaceuticals.

Figures

Figure 1
Figure 1. Phenotypic Characteristics and in vitro basophil activation of patients with inherited tryptase elevation
A, Clinical traits and vibratory challenge results independantly and significantly associated with inherited elevations in basal serum tryptase; Fisher’s exact test. B, Relative difference of CD203c MFI in affected individuals normalized to paired controls, as a percent of paired control MFI, ((Patient-Control)/Control)*100). C, Difference in %CD63+ within the CD203c+ population of affected individuals, from paired controls. Data in C and D are plotted with median ± interquartile range. *P<0.05 **P<0.01 ***P<0.005; Wilcoxon-signed rank test.
See this image and copyright information in PMC

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