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Review
. 2014 Jan 27;19(2):1432-58.
doi: 10.3390/molecules19021432.

Natural products from the genus tephrosia

Affiliations
Review

Natural products from the genus tephrosia

Yinning Chen et al. Molecules. .

Abstract

The genus Tephrosia, belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses in agriculture. This review not only outlines the source, chemistry and biological evaluations of natural products from the genus Tephrosia worldwide that have appeared in literature from 1910 to December 2013, but also covers work related to proposed biosynthetic pathways and synthesis of some natural products from the genus Tephrosia, with 105 citations and 168 new compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flavones from genus Tephrosia.
Figure 2
Figure 2
Flavonols from genus Tephrosia.
Figure 3
Figure 3
Flavanonols from genus Tephrosia.
Figure 4
Figure 4
Flavans from genus Tephrosia.
Figure 5
Figure 5
Isoflavones from genus Tephrosia.
Figure 6
Figure 6
Chalcones from genus Tephrosia.
Figure 7
Figure 7
Other flavonoids from genus Tephrosia.
Figure 8
Figure 8
Triterpenoid from genus Tephrosia.
Figure 9
Figure 9
Sesquiterpenes from genus Tephrosia.
Figure 10
Figure 10
Other compounds from genus Tephrosia.
Scheme 1
Scheme 1
Possible biogenetic pathway of compounds 46 of T. polystachyoides.
Scheme 2
Scheme 2
Possible biogenetic pathway of compounds 8 and 11.
Scheme 3
Scheme 3
Possible biogenetic pathway of compounds 3, 8, 11, 27 and 137.
Scheme 4
Scheme 4
Possible biogenetic pathway of compounds 4, 5 and 137.
Scheme 5
Scheme 5
Transform of compounds 3 and 8.
Scheme 6
Scheme 6
The synthesis of 144.

References

    1. Stevenson P.C., Kite G.C., Lewis G.P., Forest F., Nyirenda S.P., Belmain S.R., Sileshi G.W., Veitch N.C. Distinct chemotypes of Tephrosia vogelii and implications for their use in pest control and soil enrichment. Phytochemistry. 2012;78:135–146. doi: 10.1016/j.phytochem.2012.02.025. - DOI - PubMed
    1. Hegazy M.E.F., Mohamed A.E.H., El-Halawany A.M., Djemgou P.C., Shahat A.A., Pare P.W. Estrogenic activity of chemical constituents from Tephrosia candida. J. Nat. Prod. 2011;74:937–942. doi: 10.1021/np100378d. - DOI - PubMed
    1. Pelter A., Ward R.S., Rao E.V., Raju N.R. 8-Substituted flavonoids and 3'-substituted 7-oxygenated chalcones from Tephrosia purpurea. J. Chem. Soc. Perkin Trans. 1. 1981;9:2491–2498. doi: 10.1039/p19810002491. - DOI
    1. Chang L.C., Chavez D., Song L.L., Farnsworth N.R., Pezzuto J.M., Kinghorn A.D. Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea. Org. Lett. 2000;2:515–518. doi: 10.1021/ol990407c. - DOI - PubMed
    1. Chang L.C., Gerhauser C., Song L., Farnsworth N.R., Pezzuto J.M., Kinghorn A.D. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. J. Nat. Prod. 1997;60:869–873. doi: 10.1021/np970236p. - DOI - PubMed

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