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Comment
. 2014 Feb;46(2):94-5.
doi: 10.1038/ng.2881.

HOXB13, RFX6 and prostate cancer risk

Ian G Mills  1
Affiliations
Comment

HOXB13, RFX6 and prostate cancer risk

Ian G Mills. Nat Genet. 2014 Feb.

Abstract

A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

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References

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