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Review
. 2013 Nov-Dec;88(6):961-5.
doi: 10.1590/abd1806-4841.20132378.

Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood

Eugenio Galdino de Mendonça Reis-Filho  1 , Tainah de Almeida Silva  2 , Luiza Helena de Lima Aguirre  3 , Carmelia Matos Santiago Reis  1
Affiliations
Review

Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood

Eugenio Galdino de Mendonça Reis-Filho et al. An Bras Dermatol. 2013 Nov-Dec.

Erratum in

  • An Bras Dermatol. 2014 Sep-Oct;89(5):854. Dosage error in article text

Abstract
in English, Portuguese

Bullous pemphigoid is an autoimmune subepidermal blistering dermatosis that is uncommon in childhood. We report a case of a female infant, 3 months old, which presented clinical and laboratory data for the confirmatory diagnosis of bullous pemphigoid. The authors used immunohistochemical staining for collagen type IV that allowed the differentiation of bullous pemphigoid from other subepidermal bullous diseases. Opportunely we review the clinical, immunological, therapeutic and prognostic features of this pathology in children.

O penfigoide bolhoso é uma dermatose bolhosa autoimune subepidérmica, incomum na infância. Relatamos um caso de lactente feminina, com 3 meses de idade, que apresentou dados clínicos e laboratoriais confirmatórios para o diagnóstico de penfigoide bolhoso. Os autores utilizaram a coloração de imuno-histoquímica para o colágeno tipo IV que permitiu a diferenciação do penfigoide bolhoso de outras buloses subepidérmicas. Oportunamente, revisamos as características clínicas, imunológicas, terapêuticas e prognósticas da patologia na criança.

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Conflict of interest statement

Conflict of Interest: None

Figures

FIGURE 1
FIGURE 1
Presence of multiple tight, widespread vesicles in areas of normal and erythematous skin
FIGURE 6
FIGURE 6
Detail of the trunk with early lesions, and head with serohemorrhagic crusts
FIGURE 7
FIGURE 7
HE 10x: Spongiotic dermatitis with presence of subepidermal blister rich in neutrophils and eosinophils
FIGURE 10
FIGURE 10
Cryostat section with immunohistochemical reaction for type IV collagen showing positivity on the base of the blister
FIGURE 2
FIGURE 2
Detail of the right thigh with annular pruriginous erythematous plaques, some topped by blisters and tight vesicles
FIGURE 3
FIGURE 3
Detail of the left foot with serohemorrhagic crusts
FIGURE 4
FIGURE 4
Detail of the lower limbs with erythematous urticariform plaques topped by blister and vesicles
FIGURE 5
FIGURE 5
Detail of superior trunk and limbs
FIGURE 8
FIGURE 8
HE 40x: Detail of subepidermal blister rich in neutrophils and eosinophils
FIGURE 9
FIGURE 9
DIF: Positive reaction for IgG in subepidermal basal membrane zone
See this image and copyright information in PMC

References

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    1. Di Zenzo G, Della Torre R, Zambruno G, Borradori L. Bullous pemphigoid: From the clinic to the bench. Clin Dermatol. 2012;30:3–16. - PubMed
    1. Oranje AP, Vuzevski VD, van Joost T, ten Kate F, Naafs B. Bullous pemphigoid in children. Report of three cases with special emphasis on therapy. Int J Dermatol. 1991;30:339–342. - PubMed
    1. Nemeth AJ, Klein AD, Gould EW, Schachner LA. Childhood bullous pemphigoid. Clinical and immunologic features, treatment, and prognosis. Arch Dermatol. 1991;127:378–386. - PubMed
    1. Hafiji J, Bhogal B, Rytina E, Burrows NP. Bullous pemphigoid in infancy developing after the first vaccination. Clin Exp Dermatol. 2010;35:940–941. - PubMed

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