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. 2014 Jun;22(3):183-8.
doi: 10.3109/09273948.2013.844263. Epub 2014 Jan 29.

Perioperative conjunctival inflammation and trabeculectomy outcome

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Perioperative conjunctival inflammation and trabeculectomy outcome

João Marcello Furtado et al. Ocul Immunol Inflamm. 2014 Jun.

Abstract

Purpose: To correlate subclinical conjunctival inflammation and trabeculectomy results.

Methods: Prospective case series of 28 patients with primary open-angle glaucoma (28 eyes) under topical anti-glaucoma medication who underwent trabeculectomy. During surgery, a sample from the inferior bulbar conjunctiva was collected and the expression of HLA-DR together with the presence of inflammatory cells was correlated with trabeculectomy outcomes after 24 months. Surgical success was defined as intraocular pressure between 6 and 20 mmHg irrespective of the use of anti-glaucoma medication.

Results: Five patients missed follow-up visits and were removed from the study. Ten eyes (43.5%) were HLA-DR(+), but no significant differences were observed between eyes with successful and failed surgeries (p = 0.214). There was no significant association between the number of neutrophils and surgical outcomes (p = 0.353).

Conclusions: The presence of inflammatory cells and expression of the inflammation marker HLA-DR in the conjunctiva did not correlate with the prognosis of trabeculectomy in this study.

Keywords: Conjunctiva; HLA-DR; glaucoma; inflammation; trabeculectomy.

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