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Review
. 2014 Mar;24(2):1430001.
doi: 10.1142/S0129065714300010. Epub 2014 Jan 13.

Cortical excitability as a potential clinical marker of epilepsy: a review of the clinical application of transcranial magnetic stimulation

Prisca R Bauer  1 , Stiliyan Kalitzin, Maeike Zijlmans, Josemir W Sander, Gerhard H Visser
Affiliations
Review

Cortical excitability as a potential clinical marker of epilepsy: a review of the clinical application of transcranial magnetic stimulation

Prisca R Bauer et al. Int J Neural Syst. 2014 Mar.

Abstract

Transcranial magnetic stimulation (TMS) can be used for safe, noninvasive probing of cortical excitability (CE). We review 50 studies that measured CE in people with epilepsy. Most showed cortical hyperexcitability, which can be corrected with anti-epileptic drug treatment. Several studies showed that decrease of CE after epilepsy surgery is predictive of good seizure outcome. CE is a potential biomarker for epilepsy. Clinical application may include outcome prediction of drug treatment and epilepsy surgery.

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