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. 2014 Feb 12;136(6):2236-9.
doi: 10.1021/ja412107b. Epub 2014 Feb 3.

A mild Ni/Cu-catalyzed silylation via C-O cleavage

Cayetana Zarate  1 , Ruben Martin
Affiliations

A mild Ni/Cu-catalyzed silylation via C-O cleavage

Cayetana Zarate et al. J Am Chem Soc. .

Abstract

A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.

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