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. 2014 Jan 29:12:24.
doi: 10.1186/1477-7819-12-24.

Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer

Bo Yang, Fuqiu Tang, Bicheng Zhang, Yong Zhao, Junming Feng  1 , Zhiguo Rao
Affiliations

Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer

Bo Yang et al. World J Surg Oncol. .

Abstract

Background: Matrix metalloproteinase-9 (MMP-9) is an important member of the matrix metalloproteinase family and is considered to be involved in the invasion and metastasis of cancer cells. This study analyzed the expression of MMP-9 in colon cancer patients and the relationship between this expression and clinicopathological features and survival.

Methods: We immunohistochemically investigated 68 specimens of colon cancer tissues and corresponding distal normal mucosa tissues using MMP-9 antibody. Then, the correlation between MMP-9 expression and clinicopathological features and its prognostic relevance were determined.

Results: The expression rate of MMP-9 in colon cancer tissues was significantly higher than that in distal normal mucosa (69.1% versus 2.9%, P < 0.001). Significant correlations were only found between high levels of MMP-9 expression and metastasis of lymph nodes and Dukes' stage. Overexpression of MMP-9 was associated with shorter survival times in univariate analysis. Multivariate analysis confirmed that MMP-9 expression was an independent prognostic factor.

Conclusions: MMP-9 is correlated with the metastasis of lymph nodes, and its elevated expression may be an adverse prognostic indicator for the patients of colon cancer.

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Figures

Figure 1
Figure 1
Matrix metalloproteinase-9 (MMP-9) expression in colon cancer tissues. A: Positive MMP-9 expression in colon cancer tissue. The expression of MMP-9 was detected in the cytoplasm by immunohistochemistry staining (×400, SP method). B: Negative MMP-9 expression in colon cancer tissue (×400, SP method).
Figure 2
Figure 2
Kaplan-Meier survival plots of matrix metalloproteinase-9 (MMP-9) positive group and negative group. There is highly significant difference in survival rate between the MMP-9 negative group and the MMP-9 positive group (Log-rank test = 11.010, P = 0.001).
See this image and copyright information in PMC

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