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Review
. 2014 Apr;117(2):205-15.
doi: 10.1007/s11060-014-1382-9. Epub 2014 Jan 30.

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

Emmanuel Chautard  1 , Zangbéwendé Guy Ouédraogo, Julian Biau, Pierre Verrelle
Affiliations
Review

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

Emmanuel Chautard et al. J Neurooncol. 2014 Apr.

Abstract

Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.

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