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Review
. 2014 Jan 23:5:4.
doi: 10.3389/fendo.2014.00004. eCollection 2014.

Angiopoietin-like proteins: a comprehensive look

Gaetano Santulli  1
Affiliations
Review

Angiopoietin-like proteins: a comprehensive look

Gaetano Santulli. Front Endocrinol (Lausanne). .

Abstract

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.

Keywords: ANGPTL; angiopoietin-like proteins; cancer; glucose homeostasis; hematopoietic stem cells; inflammation; insulin; metabolism.

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