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. 2014 Oct;142(10):2186-94.
doi: 10.1017/S0950268813003178. Epub 2013 Dec 17.

Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection

V Friedel  1 , S Zilora  2 , D Bogaard  2 , J R Casey  1 , M E Pichichero  1
Affiliations

Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection

V Friedel et al. Epidemiol Infect. 2014 Oct.

Abstract

During a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006-June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged <5 years increased the risk of Streptococcus pneumoniae NP colonization. NP colonization with S. pneumoniae, M. catarrhalis, or Haemophilus influenzae and a family history of OM increased the risk of AOM. Risk factors that increase the risk of pneumococcal AOM will be important to reassess as we move into a new 13-valent PCV era, especially co-colonization with other potential otopathogens.

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Figures

Fig. 1.
Fig. 1.
Number of S. pneumoniae isolates by study period and circulating serotypes/serogroups. (a) Nasopharyngeal samples (total n = 548), (b) middle ear fluid samples (total n = 59). Not all circulating serotypes/serogroups are represented in this figure, as some were only present in <3 samples.
See this image and copyright information in PMC

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