Lateral junction dynamics lead the way out
- PMID: 24481041
- DOI: 10.1038/ncb2913
Lateral junction dynamics lead the way out
Abstract
Epithelial cell layers need to be tightly regulated to maintain their integrity and correct function. Cell integration into epithelial sheets is now shown to depend on the N-WASP-regulated stabilization of cortical F-actin, which generates distinct patterns of apical-lateral contractility at E-cadherin-based cell-cell junctions.
Comment on
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  Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.Nat Cell Biol. 2014 Feb;16(2):167-78. doi: 10.1038/ncb2900. Epub 2014 Jan 12. Nat Cell Biol. 2014. PMID: 24413434
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