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Comment
. 2014 Feb;16(2):129-31.
doi: 10.1038/ncb2914.

Methyltransferases modulate RNA stability in embryonic stem cells

Shuibin Lin  1 , Richard I Gregory  1
Affiliations
Comment

Methyltransferases modulate RNA stability in embryonic stem cells

Shuibin Lin et al. Nat Cell Biol. 2014 Feb.

Abstract

Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N(6)-methyladenosine (m(6)A) RNA modification in embryonic stem cells (ESCs). This m(6)A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.

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References

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