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Editorial
. 2014 Jan 31;114(3):406-8.
doi: 10.1161/CIRCRESAHA.113.303150.

Do endothelial cells eat tryptophan to die?

Charity Duran  1 , Alejandra San Martín
Affiliations
Editorial

Do endothelial cells eat tryptophan to die?

Charity Duran et al. Circ Res. .
No abstract available

Keywords: NADPH oxidase; angiotensins; endothelial cells; kynurenine; tryptophan.

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Figures

Figure 1
Figure 1
Principal metabolic outcomes of the kynurenine pathway.
Figure 2
Figure 2. Proposed model
Circulating AngII stimulates immune cells to secrete INF-γ, which induces catabolism key enzymes of Trp catabolism. The formation of 3-OH Kyn, product of the Trp degradation pathway, induces the modification and subsequent translocaltion of phox cytosolic subunits to the membrane activating NADP oxidase activity. NADPH oxidase-derived ROS reach the mitochondrial where are able to induce release of Cytochrome C and apoptosis.
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References

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