Reprogramming the cardiac field
- PMID: 24481840
- PMCID: PMC4046860
- DOI: 10.1161/CIRCRESAHA.113.302946
Reprogramming the cardiac field
Abstract
Two recent reports show that it is possible to reprogram somatic cells to a stem cell state using only a chemical cocktail or by inducing genes in tissues of engineered mice. These studies herald a time when cellular plasticity can be manipulated directly in the body to regenerate damaged tissues and organs. How do we go from these milestones to therapeutic heart regeneration?
Comment on
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Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18. Science. 2013. PMID: 23868920
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Reprogramming in vivo produces teratomas and iPS cells with totipotency features.Nature. 2013 Oct 17;502(7471):340-5. doi: 10.1038/nature12586. Epub 2013 Sep 11. Nature. 2013. PMID: 24025773
References
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- Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676. - PubMed
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- Okita K, Matsumura Y, Sato Y, et al. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011;8:409–412. - PubMed
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