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Comment
. 2014 Jan 31;343(6170):497-8.
doi: 10.1126/science.1250172.

Genetics. A unified process for neurological disease

Andrew B Singleton  1
Affiliations
Comment

Genetics. A unified process for neurological disease

Andrew B Singleton. Science. .

Abstract

The discovery of mutations associated with disease pathogenesis does not have to rest solely on genetic evidence.

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Figures

None
A global view of disease pathogenesis.
The scheme illustrates an investigative approach that connects gene mutations in one disease through protein networks. This network can be used to nominate additional candidate genes and infer mechanistic overlap with other diseases. It may be possible to derive a core network that can guide the development of therapeutics.
See this image and copyright information in PMC

Comment on

  • Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
    Novarino G, Fenstermaker AG, Zaki MS, Hofree M, Silhavy JL, Heiberg AD, Abdellateef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al-Aama JY, Abdel-Salam GMH, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben-Omran T, Mojahedi F, El Din Mahmoud IG, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, Al-Allawi N, Bindu PS, Azam M, Gunel M, Caglayan A, Bilguvar K, Tolun A, Issa MY, Schroth J, Spencer EG, Rosti RO, Akizu N, Vaux KK, Johansen A, Koh AA, Megahed H, Durr A, Brice A, Stevanin G, Gabriel SB, Ideker T, Gleeson JG. Novarino G, et al. Science. 2014 Jan 31;343(6170):506-511. doi: 10.1126/science.1247363. Science. 2014. PMID: 24482476 Free PMC article.

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