Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct;2011(1):3-13.
doi: 10.2147/VDT.S23634.

The utility of human challenge studies in vaccine development: lessons learned from cholera

Debbie-Ann T Shirley  1 , Monica A McArthur  1
Affiliations

The utility of human challenge studies in vaccine development: lessons learned from cholera

Debbie-Ann T Shirley et al. Vaccine (Auckl). 2011 Oct.

Abstract

Experiments in which virulent infectious organisms are administered to healthy adult volunteers with the intent to deliberately induce infection have been practiced for centuries. Many useful applications have developed from these experiments such as the provision of evidence of microbial pathogenicity and the identification of key virulence factors. Challenge studies have also played an important role in the evaluation of preliminary efficacy of potential vaccine candidates. Over the past 40 years, these experimental human challenge studies have found particular utility with regards to the development of both living and nonliving attenuated cholera vaccines. This review highlights some of the important contributions made by these challenge studies to cholera vaccine research.

Keywords: cholera; human challenge studies; vaccine research; virulent infectious organisms.

PubMed Disclaimer

References

    1. Miller FG, Grady C. The ethical challenge of infection-inducing challenge experiments. Clin Infect Dis. 2001 Oct 1;33(7):1028–1033. - PubMed
    1. Kotloff KL. Human challenge studies with infectious agents. J Investig Med. 2003 Feb;51(Suppl 1):S6–S11. - PubMed
    1. Levine MM. Experimental challenge studies in the development of vaccines for infectious diseases. Dev Biol Stand. 1998;95:169–174. - PubMed
    1. Levine MM. Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine. BMC Biol. 2010;8:129. - PMC - PubMed
    1. Benyajati C. Experimental cholera in humans. Br Med J. 1966 Jan 15;1(5480):140–142. - PMC - PubMed

LinkOut - more resources