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Editorial
. 2014 Feb 1;189(3):245-6.
doi: 10.1164/rccm.201312-2148ED.

Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension

Kimberly A Smith  1 , Jason X-J Yuan
Affiliations
Editorial

Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension

Kimberly A Smith et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Proposed role of hypoxia-induced hypoxia-inducible factor-1α (HIF-1α) in pulmonary hypertension and right heart failure. Hypoxia causes increased expression of HIF-1α in pulmonary arterial smooth muscle cells (PASMC), which results in increased expression of canonical transient receptor potential 6 (TRPC6), increased cytoplasmic free Ca2+ concentration ([Ca2+]cyt), and PASMC proliferation. Increased PASMC proliferation contributes to pulmonary vascular remodeling, increased pulmonary vascular resistance, and increased afterload on the right ventricle. In cardiomyocytes, the hypoxia-induced increase in HIF-1α may be a direct effect or due to coronary vascular dysfunction or reactive oxygen species. Increased expression of HIF-1α in cardiomyocytes results in increased expression of TRPC6, increased [Ca2+]cyt, and cardiomyocyte hypertrophy. Increased afterload and cardiomyocyte hypertrophy lead to right ventricular hypertrophy and right heart failure.
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