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Comment
. 2014 Feb 1;189(3):362-3.
doi: 10.1164/rccm.201305-0845LE.

Rationale for anticoagulant therapy of pulmonary fibrosis

Galina S Bogatkevich  1 , Paul J Nietert, Richard M Silver, Kristin B Highland
Affiliations
Comment

Rationale for anticoagulant therapy of pulmonary fibrosis

Galina S Bogatkevich et al. Am J Respir Crit Care Med. .
No abstract available

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Comment in

Comment on

  • A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.
    Noth I, Anstrom KJ, Calvert SB, de Andrade J, Flaherty KR, Glazer C, Kaner RJ, Olman MA; Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet). Noth I, et al. Am J Respir Crit Care Med. 2012 Jul 1;186(1):88-95. doi: 10.1164/rccm.201202-0314OC. Epub 2012 May 3. Am J Respir Crit Care Med. 2012. PMID: 22561965 Free PMC article. Clinical Trial.

References

    1. Noth I, Anstrom KJ, Calvert SB, de Andrade J, Flaherty KR, Glazer C, Kaner RJ, Olman MA Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet) A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012;186:88–95. - PMC - PubMed
    1. Chambers RC. Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? Br J Pharmacol. 2008;153:S367–S378. - PMC - PubMed
    1. Ohba T, McDonald JK, Silver RM, Strange C, LeRoy EC, Ludwicka A. Scleroderma BAL fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of the PDGF-alpha receptor. Am J Respir Cell Mol Biol. 1994;10:405–412. - PubMed
    1. Hernández-Rodríguez NA, Cambrey AD, Harrison NK, Chambers RC, Gray AJ, Southcott AM, duBois RM, Black CM, Scully MF, McAnulty RJ, et al. Role of thrombin in pulmonary fibrosis. Lancet. 1995;346:1071–1073. - PubMed
    1. Bogatkevich GS, Ludwicka-Bradley A, Nietert PJ, Akter T, van Ryn J, Silver RM. Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. Arthritis Rheum. 2011;63:1416–1425. - PMC - PubMed