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Comment
. 2014 Feb 1;189(3):363.
doi: 10.1164/rccm.201307-1328LE.

Reply: rationale for anticoagulant therapy of pulmonary fibrosis

Imre Noth  1 , Mitchell A Olman
Affiliations
Comment

Reply: rationale for anticoagulant therapy of pulmonary fibrosis

Imre Noth et al. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.
    Noth I, Anstrom KJ, Calvert SB, de Andrade J, Flaherty KR, Glazer C, Kaner RJ, Olman MA; Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet). Noth I, et al. Am J Respir Crit Care Med. 2012 Jul 1;186(1):88-95. doi: 10.1164/rccm.201202-0314OC. Epub 2012 May 3. Am J Respir Crit Care Med. 2012. PMID: 22561965 Free PMC article. Clinical Trial.
  • Rationale for anticoagulant therapy of pulmonary fibrosis.
    Bogatkevich GS, Nietert PJ, Silver RM, Highland KB. Bogatkevich GS, et al. Am J Respir Crit Care Med. 2014 Feb 1;189(3):362-3. doi: 10.1164/rccm.201305-0845LE. Am J Respir Crit Care Med. 2014. PMID: 24484337 Free PMC article. No abstract available.

References

    1. Chambers RC, Scotton CJ. Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc. 2012;9:96–101. - PubMed
    1. Noth I, Anstrom KJ, Calvert SB, de Andrade J, Flaherty KR, Glazer C, Kaner RJ, Olman MA Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet) A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012;186:88–95. - PMC - PubMed
    1. Bogatkevich GS, Ludwicka-Bradley A, Silver RM. Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. Arthritis Rheum. 2009;60:3455–3464. - PMC - PubMed
    1. Bogatkevich GS, Ludwicka-Bradley A, Nietert PJ, Akter T, van Ryn J, Silver RM. Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. Arthritis Rheum. 2011;63:1416–1425. - PMC - PubMed
    1. Wygrecka M, Didiasova M, Berscheid S, Piskulak K, Taborski B, Zakrzewicz D, Kwapiszewska G, Preissner KT, Markart P. Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis. Thromb Haemost. 2013;110:295–307. - PubMed