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. 2014 Mar 15;268(1-2):84-8.
doi: 10.1016/j.jneuroim.2014.01.004. Epub 2014 Jan 16.

Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?

Chiara Boiocchi  1 , Cecilia Osera  2 , Maria Cristina Monti  3 , Ottavia Eleonora Ferraro  3 , Stefano Govoni  2 , Mariaclara Cuccia  4 , Cristina Montomoli  3 , Alessia Pascale  2 , Roberto Bergamaschi  5
Affiliations

Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?

Chiara Boiocchi et al. J Neuroimmunol. .

Abstract

Genetic and environmental factors contribute to disease Multiple Sclerosis (MS) susceptibility, the most prevalent neurological pathology affecting young individuals in Western countries. We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions. Genotype analysis of HSP70-2 (+1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of MS (OR:1.31, 95% CI: 1.02-1.69, P = 0.039). In addition, Hsp70-2 protein content in vitro from PBMC was significantly lower in MS patients with GG genotype compared to AA genotype, indicating an implication of the G allele of HSP70-2 gene polymorphism in the development of MS.

Keywords: HSP70-2 (+1267 A/G) polymorphism; Multiple Sclerosis; Neuroinflammation.

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