Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan 28;331(6154):315-9.
doi: 10.1038/331315a0.

Purification and reconstitution of the calcium release channel from skeletal muscle

F A Lai  1 , H P Erickson, E Rousseau, Q Y Liu, G Meissner
Affiliations

Purification and reconstitution of the calcium release channel from skeletal muscle

F A Lai et al. Nature. .

Abstract

The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources