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Review
. 2014 Apr:35:14-7.
doi: 10.1016/j.matbio.2014.01.014. Epub 2014 Jan 30.

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Vincent C Hascall  1 , Aimin Wang  2 , Markku Tammi  3 , Sanna Oikari  3 , Raija Tammi  3 , Alberto Passi  4 , Davide Vigetti  4 , Richard W Hanson  5 , Gerald W Hart  6
Affiliations
Review

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Vincent C Hascall et al. Matrix Biol. 2014 Apr.

Abstract

Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space. The cellular metabolism (synthesis and catabolism) of hyaluronan is dynamic. UDP-GlcNAc is also the substrate for O-GlcNAc transferase, which is central to the control of many cytosolic pathways. This Perspective outlines recent data for regulation of hyaluronan synthesis and catabolism that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDP-GlcNAc concentrations in order to maintain normal cell functions.

Keywords: Hyaluronan; Hyaluronan synthases; O-GlcNAc transferase; UDP-GlcNAc.

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