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. 2014 Feb 1;592(3):411-4.
doi: 10.1113/jphysiol.2013.262261.

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

Affiliations

CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

Marc Pourrier et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
A pathological enhanced INa,L contributes to Na+-dependent Ca2+ overload, diastolic dysfunction

Comment in

References

    1. Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas AF, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA. Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat. Am J Physiol Heart Circ Physiol. 2013;305:H1068–H1079. - PMC - PubMed
    1. Belardinelli L, Liu G, Smith-Maxwell C, Wang WQ, El Bizri N, Hirakawa R, Karpinski S, Li CH, Hu L, Li XJ, Crumb W, Wu L, Koltun D, Zablocki J, Yao L, Dhalla AK, Rajamani S, Shryock JC. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. J Pharmacol Exp Ther. 2013;344:23–32. - PubMed
    1. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011;32:670–679. - PMC - PubMed
    1. Coppini R, Ferrantini C, Yao L, Fan P, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Yacoub M, Olivotto I, Belardinelli L, Poggesi C, Cerbai E, Mugelli A. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy. Circulation. 2013;127:575–584. - PubMed
    1. Derangeon M, Montnach J, Baró I, Charpentier F. Mouse models of SCN5A-related cardiac arrhythmias. Front Physiol. 2012;3:210. - PMC - PubMed

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