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Case Reports
. 2014;18(2):190-3.

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature

M Internullo  1 , V Giannelli, L Sardo, C Antonaglia, T Villani, E Angelici, P Palange
Affiliations
  • PMID: 24488907
Free article
Case Reports

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature

M Internullo et al. Eur Rev Med Pharmacol Sci. 2014.
Free article

Abstract

Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.

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