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. 2013:2013:809382.
doi: 10.1155/2013/809382. Epub 2013 Dec 30.

Prognosis of multifocal papillary thyroid carcinoma

Sheng-Fong Kuo  1 , Shu-Fu Lin  1 , Tzu-Chieh Chao  2 , Chuen Hsueh  3 , Kun-Ju Lin  4 , Jen-Der Lin  1
Affiliations

Prognosis of multifocal papillary thyroid carcinoma

Sheng-Fong Kuo et al. Int J Endocrinol. 2013.

Abstract

This study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed with multifocal PTC. The percentage of multifocal PTC was higher in PTMC patients (22.0%) than in non-PTMC patients (19.5%). Demographic and clinical characteristics of PTMC and multifocal PTC in PTC patients were traced. Multifocal PTC patients presented with smaller tumors at an older age, and a higher percentage underwent total or complete thyroidectomy. These patients also showed a higher incidence of postoperative disease progression than did unifocal PTC patients. Comparison of 483 patients with multifocal PTMC and non-PTMC tumors showed a higher incidence of postoperative disease progression in patients with non-PTMC; otherwise, there was no statistical difference in disease-specific and total mortality between these two groups. In conclusion, the incidence of multifocal PTMC was not lower than that of non-PTMC, and postoperative therapies were necessary for both multifocal PTMC and non-PTMC patients.

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Figures

Figure 1
Figure 1
Number of papillary thyroid carcinoma (PTC) patients and percentage of papillary thyroid microcarcinoma and multifocal PTC during different periods.
Figure 2
Figure 2
Cancer-specific survival curves (a) and progression-free rates (b) for multifocal papillary microcarcinoma and non-PTMC groups.
See this image and copyright information in PMC

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