doi: 10.1155/2013/568364.
Epub 2014 Jan 16.
Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report
Affiliations
- PMID: 24489552
- PMCID: PMC3899707
- DOI: 10.1155/2013/568364
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Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report
Case Rep Med.
2013.
Abstract
Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the most common antibody in cases reported. We report a case of posttransfusion purpura in an African American. The patient was negative for HPA-1a antibodies, but anti-HPA-1b was identified with a platelet phenotype of HPA-1a/HPA-1a. Although less common, HPA-1b antibody may be an important consideration in posttransfusion purpura diagnosed in patients of African descent.
Figures
Chart showing trend of platelet count.
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