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. 2013:2013:568364.
doi: 10.1155/2013/568364. Epub 2014 Jan 16.

Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report

O P Arewa  1 , S Nahirniak  2 , G Clarke  2
Affiliations

Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report

O P Arewa et al. Case Rep Med. 2013.

Abstract

Posttransfusion purpura (PTP) is an uncommon, but potentially fatal, transfusion reaction characterized by profound thrombocytopenia and bleeding. PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. Although there is evidence of a wide serological spectrum of culprit antibodies implicated, Anti-human-platelet-antigen- (HPA-) 1a is the most common antibody in cases reported. We report a case of posttransfusion purpura in an African American. The patient was negative for HPA-1a antibodies, but anti-HPA-1b was identified with a platelet phenotype of HPA-1a/HPA-1a. Although less common, HPA-1b antibody may be an important consideration in posttransfusion purpura diagnosed in patients of African descent.

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Figures

Figure 1
Figure 1
Chart showing trend of platelet count.
See this image and copyright information in PMC

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