HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

doi:10.1155/2013/982759

. 2013 Winter;24(4):202-8.

doi: 10.1155/2013/982759.

HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

Cécile Tremblay¹, Isabelle Hardy², Richard Lalonde³, Benoit Trottier⁴, Irina Tsarevsky⁵, Louis-Philippe Vézina⁶, Michel Roger², Mark Wainberg⁷, Jean-Guy Baril⁸

Affiliations

¹ Centre hospitalier de l'Université de Montréal; ; Laboratoire de santé publique du Québec;
² Centre hospitalier de l'Université de Montréal; ; HIV Genotyping Program;
³ McGill University Health Centre; ; Advisory Committee on the Clinical Management of Persons Living with HIV;
⁴ Centre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale l'Actuel;
⁵ Advisory Committee on the Clinical Management of Persons Living with HIV; ; Service de lutte contre les infections transmissibles sexuellement et par le sang, ministère de la Santé et des Services sociaux;
⁶ Advisory Committee on the Clinical Management of Persons Living with HIV; ; Programme national de mentorat sur le VIH-sida;
⁷ McGill AIDS Centre; ; McGill University, Montreal, Quebec;
⁸ Centre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale du Quartier Latin.

PMID: 24489562
PMCID: PMC3905003
DOI: 10.1155/2013/982759

HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

Cécile Tremblay et al. Can J Infect Dis Med Microbiol. 2013 Winter.

. 2013 Winter;24(4):202-8.

doi: 10.1155/2013/982759.

Authors

Cécile Tremblay¹, Isabelle Hardy², Richard Lalonde³, Benoit Trottier⁴, Irina Tsarevsky⁵, Louis-Philippe Vézina⁶, Michel Roger², Mark Wainberg⁷, Jean-Guy Baril⁸

Affiliations

¹ Centre hospitalier de l'Université de Montréal; ; Laboratoire de santé publique du Québec;
² Centre hospitalier de l'Université de Montréal; ; HIV Genotyping Program;
³ McGill University Health Centre; ; Advisory Committee on the Clinical Management of Persons Living with HIV;
⁴ Centre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale l'Actuel;
⁵ Advisory Committee on the Clinical Management of Persons Living with HIV; ; Service de lutte contre les infections transmissibles sexuellement et par le sang, ministère de la Santé et des Services sociaux;
⁶ Advisory Committee on the Clinical Management of Persons Living with HIV; ; Programme national de mentorat sur le VIH-sida;
⁷ McGill AIDS Centre; ; McGill University, Montreal, Quebec;
⁸ Centre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale du Quartier Latin.

PMID: 24489562
PMCID: PMC3905003
DOI: 10.1155/2013/982759

Abstract
in English, French

HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.

Les tests de détermination du tropisme du VIH-1 jouent un rôle capital dans la détermination de la réponse aux antagonistes des récepteurs du CCR5. Au début, on utilisait des tests phénotypiques, mais leur accès limité a suscité l’élaboration d’autres stratégies. Récemment, le génotypage du tropisme a été validé à l’aide d’une technologie canadienne, dans le cadre d’essais cliniques faisant appel au maraviroc tant chez des patients déjà en traitement que chez des patients naïfs au traitement. Les présentes lignes directrices passent en revue les données probantes en appui à l’utilisation de tests génotypiques et contiennent des recommandations au sujet des tests de détermination du tropisme dans la prise en charge clinique quotidienne.

Keywords: CCR5; HIV; Maraviroc; Tropism.

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References

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[1] Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. < www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf> (Accessed August 3, 2012)

[2] Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. < www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf> (Accessed August 3, 2012)

[3] Doms RW. Unwelcome guests with master keys: How HIV enters cells and how it can be stopped. Top HIV Med. 2004;12:100–3. - PubMed

[4] Doms RW. Unwelcome guests with master keys: How HIV enters cells and how it can be stopped. Top HIV Med. 2004;12:100–3. - PubMed

[5] Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature. 1998;393:648–59. - PMC - PubMed

[6] Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature. 1998;393:648–59. - PMC - PubMed

[7] Kwong PD. Human immunodeficiency virus: Refolding the envelope. Nature. 2005;433:815–6. - PubMed

[8] Kwong PD. Human immunodeficiency virus: Refolding the envelope. Nature. 2005;433:815–6. - PubMed

[9] Labrosse B, Treboute C, Brelot A, Alizon M. Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor. J Virol. 2001;75:5457–64. - PMC - PubMed

[10] Labrosse B, Treboute C, Brelot A, Alizon M. Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor. J Virol. 2001;75:5457–64. - PMC - PubMed

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HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

Affiliations

HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations

Authors

Affiliations

Abstract
in English, French

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Cited by

References

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Abstract in English, French

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References

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Abstract
in English, French