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. 2013:2013:201857.
doi: 10.1155/2013/201857. Epub 2013 Dec 30.

The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV

Yuwen Cen  1 , Ross Ka-Kit Leung  2 , Fuchun Zhang  1 , Weidong Jia  1 , Jiansheng Zhang  1 , Xinghua Tan  1 , Feilong Xu  1
Affiliations

The Association between Yang-Deficient Constitution and Clinical Outcome of Highly Active Antiretroviral Therapy on People Living with HIV

Yuwen Cen et al. Evid Based Complement Alternat Med. 2013.

Abstract

Objective. To determine the association between Yang-Deficient Constitution and the clinical outcomes of HIV/AIDS patients who have initiated highly active antiretroviral therapy (HAART). Method. A total of 197 antiretroviral-naive adults who initiated HAART between 2009 and 2011 were recruited. The participants were asked to complete a questionnaire twice to assess their Yang-Deficient Constitution status before HAART. During the study, signs and symptoms and CD4 or CD8 T cell counts were recorded. Routine blood and biochemical tests were conducted. For the patients who were found to have infections, pathologic examination was performed. Statistical test of association of clinical attributes and demographic factors with Yang-Deficient Constitution was conducted. Result. Good test-retest reliability was observed for Yang-Deficient Constitution scoring. The median Yang-Deficient Constitution score of 142 eligible participants was 25. Female (score = 32.14, P < 0.05), hepatotoxicity (32.14, P < 0.1), nephrotoxicity (37.50, P < 0.1), total number of adverse events (P < 0.1), and mortality (39.29, P < 0.05) were associated with Yang-Deficient Consitution, while annual changes or nadir values of CD4 or CD8 T lymphocytes, and newly acquired infections after starting HAART were not. Mortality was also associated with total number of adverse events (P < 0.05), hepatotoxicity (P < 0.05), and nephrotoxicity (P < 0.05). Conclusion. Yang-Deficient Constitution score has a potential to be developed as a predictor for early HIV-related mortality and side effects. The interrelation and underlying mechanisms should be further investigated for evidence-based design of a more appropriate treatment strategy.

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Figures

Figure 1
Figure 1
Change of CD4 and CD8 count over a one-year period during receiving HAART. ((a), (b)) units for the scale prototypic CD4 (a) and CD8 (b) change and the number of cases assigned. ((c), (d)) Convergence was attained at about the 50th iteration for both CD4 and CD8 profile analyses.
Figure 2
Figure 2
A hypothesis derived from the key findings about Yang-Deficient Constitution and clinical outcomes of AIDS patients. PLHIV: people living with HIV; HAART: highly active antiretroviral therapy.
See this image and copyright information in PMC

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